What it is
MOTS-c is encoded by a short open reading frame inside the mitochondrial 12S rRNA gene. It is one of a small group of peptides made from mitochondrial rather than nuclear DNA.
What researchers study
- Studied in metabolism research. In cell and mouse studies it acts on the folate cycle and AMPK signaling.
- Under stress it can move into the cell nucleus, which is an active research topic.
Specifications
| Sequence | MRWQEMGYIFYPRKLR |
| Molecular formula | C101H152N28O22S2 |
| Molecular weight | 2174.6 g/mol |
| PubChem | CID 146675088 |
| Form | Lyophilized powder |
| Vial sizes | 10 mg |
| Storage | Unopened: 2 to 8 °C, away from light |
How each lot is tested
Samples from every lot go to an independent, ISO/IEC 17025 accredited lab. Its report covers three tests:
- Purity by reversed-phase HPLC: the main peak's share of the total peak area.
- Identity by mass spectrometry: the observed mass should match the expected 2174.6 g/mol.
- Endotoxin, measured for every lot.
The lot number on your vial is the number on its report. How to check a certificate of analysis walks through what to look for.
The amount on the label is the weight of the powder. Besides the peptide it includes counter-ions and some water; Purity vs. peptide content explains the difference.
Storage and handling
Store unopened vials at 2 to 8 °C, away from light, as printed on the label. Let a cold vial reach room temperature before you open it, so moisture doesn't condense on the powder. More bench habits are in Handling.
For laboratory research use only. Not for human or veterinary use. This page describes the compound and published research on it. It is not a recommendation for any use.