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PNC-27

HDM-2 binding peptide

A p53 fragment joined to a cell-penetrating sequence.

Vial size

Signaling and otherHPLC · MS · Endotoxin

PNC-27 5 mg research vial

What it is

PNC-27 joins residues 12–26 of p53, the region that binds HDM-2, to a penetratin-type membrane sequence.

What researchers study

  • Studied in cancer-cell research, where it binds HDM-2 at the cell membrane and forms pores in tumor cell lines.

Specifications

SequencePPLSQETFSDLWKLLKKWKMRRNQFWVKVQRG
Molecular formulaC188H293N53O44S
Molecular weight4031.7 g/mol
PubChemCID 16201774
FormLyophilized powder
Vial sizes5 mg
StorageUnopened: 2 to 8 °C, away from light

How each lot is tested

Samples from every lot go to an independent, ISO/IEC 17025 accredited lab. Its report covers three tests:

  • Purity by reversed-phase HPLC: the main peak's share of the total peak area.
  • Identity by mass spectrometry: the observed mass should match the expected 4031.7 g/mol.
  • Endotoxin, measured for every lot.

The lot number on your vial is the number on its report. How to check a certificate of analysis walks through what to look for.

The amount on the label is the weight of the powder. Besides the peptide it includes counter-ions and some water; Purity vs. peptide content explains the difference.

Storage and handling

Store unopened vials at 2 to 8 °C, away from light, as printed on the label. Let a cold vial reach room temperature before you open it, so moisture doesn't condense on the powder. More bench habits are in Handling.

For laboratory research use only. Not for human or veterinary use. This page describes the compound and published research on it. It is not a recommendation for any use.