What it is
Amyloid-β is released from the amyloid-β A4 precursor protein (APP) by β- and γ-secretase. It is the main component of amyloid plaques.
What researchers study
- Used to model aggregation, oligomer formation and neurotoxicity in Alzheimer's disease research.
- How it is dissolved and pre-treated strongly affects its aggregation state, so methods should report it.
Specifications
| Form | Lyophilized powder |
| Vial sizes | 0.5 mg |
| Storage | Unopened: 2 to 8 °C, away from light |
How each lot is tested
Samples from every lot go to an independent, ISO/IEC 17025 accredited lab. Its report covers three tests:
- Purity by reversed-phase HPLC: the main peak's share of the total peak area.
- Identity by mass spectrometry: the observed mass is checked against the expected mass.
- Endotoxin, measured for every lot.
The lot number on your vial is the number on its report. How to check a certificate of analysis walks through what to look for.
The amount on the label is the weight of the powder. Besides the peptide it includes counter-ions and some water; Purity vs. peptide content explains the difference.
Storage and handling
Store unopened vials at 2 to 8 °C, away from light, as printed on the label. Let a cold vial reach room temperature before you open it, so moisture doesn't condense on the powder. More bench habits are in Handling.
For laboratory research use only. Not for human or veterinary use. This page describes the compound and published research on it. It is not a recommendation for any use.