CJC-1295 DAC · Modified GRF 1-29 with DAC

What it is

CJC-1295 DAC is Modified GRF 1-29 with one more lysine at the C-terminus. That lysine carries a maleimide group, the Drug Affinity Complex. The maleimide bonds to a free cysteine on albumin, so the peptide rides on albumin and is cleared slowly.

What researchers study

GHRH receptor agonist with a much longer half-life than GRF 1-29 in pharmacology studies.
Used to study sustained GHRH receptor signaling and its effect on growth hormone and IGF-1 levels.

Specifications

Sequence	`Y-(D-Ala)-DAIFTQSYRKVLAQLSARKLLQDILSR-K(MPA)-NH2`K(MPA) is lysine with a maleimidopropionyl group on its side chain: the Drug Affinity Complex.
Molecular formula	C₁₆₅H₂₆₉N₄₇O₄₆
Molecular weight	3647.2 g/mol
PubChem	CID 91971820
Form	Lyophilized powder
Vial sizes	2 mg
Storage	Unopened: 2 to 8 °C, away from light

How each lot is tested

Samples from every lot go to an independent, ISO/IEC 17025 accredited lab. Its report covers three tests:

Purity by reversed-phase HPLC: the main peak's share of the total peak area.
Identity by mass spectrometry: the observed mass should match the expected 3647.2 g/mol.
Endotoxin, measured for every lot.

The lot number on your vial is the number on its report. How to check a certificate of analysis walks through what to look for.

The amount on the label is the weight of the powder. Besides the peptide it includes counter-ions and some water; Purity vs. peptide content explains the difference.

Storage and handling

Store unopened vials at 2 to 8 °C, away from light, as printed on the label. Let a cold vial reach room temperature before you open it, so moisture doesn't condense on the powder. More bench habits are in Handling.

For laboratory research use only. Not for human or veterinary use. This page describes the compound and published research on it. It is not a recommendation for any use.