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G3-RETA

Retatrutide (LY3437943)

A 39-residue lipidated peptide that acts on three receptors: GIP, GLP-1 and glucagon.

Vial size

Incretin analogsHPLC · MS · Endotoxin

G3-RETA 10 mg research vial

What it is

G3-RETA is retatrutide, first described in 2022 under the code LY3437943. It is a single 39-residue peptide built on a GIP backbone, with two Aib residues and an α-methyl-leucine that resist enzymatic breakdown. A C20 fatty diacid on lysine 17 binds albumin, which slows clearance.

What researchers study

  • Agonist at three receptors at once: GIP, GLP-1 and glucagon. It is often called a triple agonist.
  • Used to study how combined incretin and glucagon-receptor signaling affects energy balance and glucose handling in cell and rodent models.
  • An investigational compound. Clinical trials are run by its developer, not by research suppliers.

Specifications

SequenceY-Aib-QGTFTSDYSI-αMeL-LDK-K*-AQ-Aib-AFIEYLLEGGPSSGAPPPS-NH2K* carries a C20 fatty diacid on a γ-Glu and AEEA linker. Aib is 2-aminoisobutyric acid; αMeL is α-methyl-leucine.
Molecular formulaC221H342N46O68
Molecular weight4731.3 g/mol
FormLyophilized powder
Vial sizes10 mg
StorageUnopened: 2 to 8 °C, away from light

How each lot is tested

Samples from every lot go to an independent, ISO/IEC 17025 accredited lab. Its report covers three tests:

  • Purity by reversed-phase HPLC: the main peak's share of the total peak area.
  • Identity by mass spectrometry: the observed mass should match the expected 4731.3 g/mol.
  • Endotoxin, measured for every lot.

The lot number on your vial is the number on its report. How to check a certificate of analysis walks through what to look for.

The amount on the label is the weight of the powder. Besides the peptide it includes counter-ions and some water; Purity vs. peptide content explains the difference.

Storage and handling

Store unopened vials at 2 to 8 °C, away from light, as printed on the label. Let a cold vial reach room temperature before you open it, so moisture doesn't condense on the powder. More bench habits are in Handling.

For laboratory research use only. Not for human or veterinary use. This page describes the compound and published research on it. It is not a recommendation for any use.