PYY 3-36

What it is

Peptide YY is a 36-residue hormone made by L-cells in the lower intestine. The enzyme DPP-4 trims its first two residues to give PYY 3-36, the form that dominates in circulation.

What researchers study

• Selective agonist at the Y2 receptor of the neuropeptide Y family.
• Used in research on gut-to-brain appetite signaling, especially in the hypothalamus.
• Also studied in research on gut motility and fluid secretion.

Specifications

How each lot is tested

Samples from every lot go to an independent, ISO/IEC 17025 accredited lab. Its report covers three tests:

• Purity by reversed-phase HPLC: the main peak's share of the total peak area.
• Identity by mass spectrometry: the observed mass should match the expected 4049.5 g/mol.
• Endotoxin, measured for every lot.

The lot number on your vial is the number on its report. How to check a certificate of analysis walks through what to look for.

The amount on the label is the weight of the powder. Besides the peptide it includes counter-ions and some water; Purity vs. peptide content explains the difference.

Storage and handling

Store unopened vials at 2 to 8 °C, away from light, as printed on the label. Let a cold vial reach room temperature before you open it, so moisture doesn't condense on the powder. More bench habits are in Handling.